The Cancer Research UK City of London (CoL) Centre is a world class hub for cancer biotherapeutics. It brings together researchers from four of the central London Cancer Research UK centres: University College London, King’s College London, Barts / Queen Mary University of London and The Francis Crick Institute. This unique interdisciplinary and collaborative network will generate novel innovative biological therapies, diagnostics and stratification strategies in addition to providing a clinical and translational pipeline for cancer discovery science.