The Advanced Cell Engineering Core is based at the UCL Cancer Institute, Paul O’Gorman building. The Advanced Cellular Engineering Core comprises two sections 1) Cell Engineering and 2) Gene Editing.

The function of the core is to support the development of novel approaches to cell therapies through expression of exogenous/synthetic chimeric proteins using viral vectors and/or through the use of genome editing tools. The scope of the core is broad and covers basic, preclinical and translational projects.

In the former, the Core utilizes the gamma-retroviral and lentiviral vectors for the introduction of genetic material into mammalian cells.

In the latter, the Core has access to the Lonza 4D-Nucleofector X-Unit and the MaxCyte STx electroporation systems for the delivery of genetic material on an R&D scale.

Please see the UCL CAR T-cell Programme page to learn more about our research.