Latest publications
Risk-Adapted Breast Screening for Women at Low Predicted Risk of Breast Cancer: An Online Discrete Choice Experiment
CoL Centre faculty: Jo Waller and Suzanne Scott
Med Decis Making, Jun 2024
Awareness and knowledge about HPV and primary HPV screening among women in Great Britain: An online population-based survey
CoL Centre faculty: Jo Waller
J Med Screen, Jun 2024
Patient Specific Colorectal Cancer-Associated Fibroblasts Modulate Tumour Microenvironment Mechanics
CoL Centre faculty: Umber Cheema
Cell, 20th May 2024
Palmitoyl transferase ZDHHC20 promotes pancreatic cancer metastasis
CoL Centre faculty: Julian Downward
Cell reports, 15th May 2024
Loss of POLE3-POLE4 unleashes replicative gap accumulation upon treatment with PARP inhibitors
CoL Centre faculty: Roberto Bellelli
Cell reports, 15th May 2024
Considerations for using potential surrogate endpoints in cancer screening trials
CoL Centre faculty: Peter Sasieni
Lancet Oncology, 5th May 2024
Risk of T-cell Malignancy Following CAR T cells in Children, Adolescents and Young Adults
CoL Centre faculty: Sara Ghorashian
Blood Advances, 3rd May 2024
Hematopoietic stem cell quiescence and DNA replication dynamics maintained by the resilient β-catenin/Hoxa9/Prmt1 axis
CoL Centre faculty: Eric So
Blood, 18th April 2024
Mutations in the splicing factor SF3B1 are linked to frequent emergence of HLA-DRlow/neg monocytes in lower-risk myelodysplastic neoplasms
CoL Centre faculty: Shahram Kordasti
Nature, 17th April 2024
Spatial Architecture of Myeloid and T Cells Orchestrates Immune Evasion and Clinical Outcome in Lung Cancer
CoL Centre faculty: Kristiana Grigoriadis, Allan Hackshaw, Mariam Jamal-Hanjani, Nicholas McGranahan, James L Reading, Sergio A Quezada, Crispin T Hiley, Julian Downward, Erik Sahai, Charles Swanton
Cancer Discovery, 6th April 2024
Versican associates with tumour immune phenotype and limits T cell trafficking via chondroitin sulfate
CoL Centre faculty: Oliver Pearce
AACR Journals, 22nd March 2024
Drug-resistant EGFR mutations promote lung cancer by stabilizing interfaces in ligand-free kinase-active EGFR oligomers
CoL Centre faculty: Gilbert O. Fruhwirth and Peter Parker
Nature Comms, 19th March 2024
Metabolic priming by multiple enzyme systems supports glycolysis, HIF1α stabilisation, and human cancer cell survival in early hypoxia
CoL Centre faculty:
EMBO journal, 14th March 2024
Noncoding mutations drive persistence of a founder preleukemic clone which initiates late relapse in T-ALL
CoL Centre faculty:
Blood, 7th March 2024
ZAP-70 augments tonic B-cell receptor and CCR7 signaling in IGHV–unmutated chronic lymphocytic leukemia
CoL Centre faculty: Ingo Ringshausen
Blood Advances, 1st March 2024
Nilotinib in KIT-driven advanced melanoma: Results from the phase II single-arm NICAM trial
CoL Centre faculty: Samra Turajlic
Cell reports Medicine, 27th February 2024
Apparent RNA bridging between PRC2 and chromatin is an artifact of non-specific chromatin precipitation upon RNA degradation
CoL Centre faculty: Richard Jenner
Cell reports, 27th February 2024
Protein degradation by human 20S proteasomes elucidates the interplay between peptide hydrolysis and splicing
CoL Centre faculty: Michele Mishto
Nature Comms, 7th Feb 2024
Deep Learning Enables Spatial Mapping of the Mosaic Microenvironment of Myeloma Bone Marrow Trephine Biopsies
CoL Centre faculty: Lydia Lee, Manuel Rodriguez-Justo, Kwee Yong
Cancer Research, 1st Feb 2024
High pretreatment disease burden as a risk factor for infectious complications following CD19 chimeric antigen receptor T-cell therapy for large B-cell lymphoma
CoL Centre faculty: Claire Roddie
HemaSphere, 26th Jan 2024
New method to reveal proteins that bind to specific RNA regions in living cells described
CoL Centre faculty: Faraz Mardakheh and Lovorka Stojic
Nature Methods, 16th Jan 2024
mRNA therapy corrects a rare liver genetic disease known as argininosuccinic aciduria (ASA) in a mouse model of the disease by replacing the defective urea cycle gene and restore its function
CoL Centre faculty:
Science Translational Medicine 10th Jan 2024
Non-coding mutations drive persistence of a founder pre-leukemic clone which initiates late relapse in T-ALL
CoL Centre faculty:
Blood 9th Jan 2024
PD-1 defines a distinct, functional, tissue-adapted state in Vδ1+ T cells with implications for cancer immunotherapy
CoL Centre faculty:
Nature Cancer, 3rd Jan 2024
An oncogenic phenoscape of colonic stem cell polarization
CoL Centre faculty:
Cell 7th Dec 2023
Trellis tree-based analysis reveals stromal regulation of patient-derived organoid drug responses
CoL Centre faculty:
Cell 7th Dec 2023
The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance
CoL Centre faculty: Mariam Jamal-Hanjani, Karen H. Vousden, Nicholas McGranahan, Nnennaya Kanu, Charles Swanton
Nature Genetics 4th Dec 2023
Impact of MYC and BCL2 double expression on outcomes in Primary CNS Lymphoma: a UK multicenter analysis
CoL Centre faculty: Jessica Okosun
Blood advances 1st Dec 2023
Cranial radiotherapy has minimal benefit in children with central nervous system involvement in T-ALL
CoL Centre faculty: David O’Connor
Blood advances 30th Nov 2023
SYK ubiquitination by CBL E3 ligases restrains cross-presentation of dead cell-associated antigens by type 1 dendritic cells – Cell reports 28/11/23
Multi-scale characterisation of homologous recombination deficiency in breast cancer – Genome Medicine 2/11/23
Drug mechanism opens door for new anti-cancer immunotherapies – Blood 12/10/23
The mutational landscape of the adult healthy parous and nulliparous human breast – Nature Comms 6/09/23
Tumor heterogeneity impairs immunogenicity in mismatch repair deficient tumors – Nature Genetics 27/09/23
Copy number architectures define treatment-mediated selection of lethal prostate cancer clones – Nature comms 10/8/23
Mutational signature dynamics shaping the evolution of oesophageal adenocarcinoma – Nature Comms 15/7/23
Safety and anti-tumour activity of the IgE antibody MOv18 in patients with advanced solid tumours expressing folate receptor-alpha: a phase I trial – Nature 25/7/23
Extracellular matrix educates an immunoregulatory tumor macrophage phenotype found in ovarian cancer metastasis – Nature Comms 05/23
Transcriptional signatures associated with persisting CD19 CAR-T cells in children with leukemia– Nature Medicine 6/7/23
AI model predicts if breast cancer will spread based on lymph node changes – The Times, The Independent, The Sun, The Daily Mail, ITV , Sky, The Glasgow Evening Times 26/5/23
A study led by Alan Ramsay reveals that targeting the tumour environment could improve immunotherapy responses for lymphoma patients – JCI 23/5/2023
Computer model reveals how early-stage skin cancer can stay ‘invisible’ to immune cells – Science advances 12/5/23
Bowelbabe will fund the project “Using artificial intelligence and blood tests to detect the earliest signs of cancer” led by Dr Oleg Blyuss (QMUL) –Evening Standard 5/4/2023
eDyNAmiC grand challenge team (including Benjamin Werner and Mariam Jamal-Hanjani): ‘Bond villain’ DNA could transform cancer treatment – The Guardian 18/2/2023
Personalised and powerful: UK to lead next-generation radiotherapy research – CRUK, 04/11/2019
London experts join forces in ‘grand coalition’ to transform cancer treatment – Evening Standard, 17/09/2018
London biotherapeutics powerhouse launched by Cancer Research UK – PHARMAfield, 17/09/2018
UCL key partner in £14m cancer biotherapeutics research hub – UCL, 17/09/2018
London cancer hub launched by Cancer Research UK – PMLiVE, 18/09/2018
Crick key partner in £14m cancer biotherapeutics research centre – The Francis Crick Institute, 18/09/2018
King’s College London to be part of cancer funding boost – National Institute for Health Research, 18/09/2018
Cancer treatment to be revolutionised at new multi-million pound research hub – King’s College London, 20/09/2018
Cancer Research UK unveils CRUK City of London Centre – Zenopa, 25/09/2018